The 2019’s Global Health Security (GHS) Index has identified the Democratic People’s Republic of Korea (DPRK) as the ‘least prepared’ nation in terms of its overall level of health related security preparedness (GHS 2019). The country had much greater level of vulnerability to health problems and a minimum level of preparedness. In the wake of the year 2020, the overall health security conditions of the DPRK seem to remain unchanged. With the unprecedented COVID-19 outbreak across 209 nations since the late 2019, the case of the DPRK has been extremely worrisome. Meantime, virtually every nation in the world is currently suffering from the COVID-19 threats. This paper therefore attempts to analyze degree of preparedness (if any) and vulnerability to health security conditions using the Infectious Disease Vulnerability Index (IDVI) Framework. Based on the vulnerability assessments, this paper contends that transnational advocacy networks (TAN) formed humanitarian aid operations by International Organizations (IOs) and International Non-Governmental Organizations (INGOs) will not only make contributions in helping the citizens manage potential COVID-19 outbreaks but induce positive change to the application of human rights to the health sector in the DPRK.