Objectives: This study was undertaken by the department of Korean neuropsychiatry, to evaluate the effects of M&L psychotherapy and Korean Medical Treatments on hospitalized North Korean defectors.Methods: We treated two patients with indigenous Korean medical therapies (acupuncture and herb-medicine) and M&L psychotherapy. Beck's Depression Inventory (BDI), Insomnia Severity Index (ISI), Geriatric Depression Scale (GDS), Mini-mental state examination Korean Version (MMSE-K), and Visual Analogue Scale (VAS) were used to evaluate the patients.Results: Following observations were made after treatments. Case 1: the patient had significant im-provement in Beck's Depression Inventory (BDI), Insomnia Severity Index (ISI), and Visual Analogue Scale (VAS). Case 2: similar improvements were observed. Here, the patient had undergone Geriatric Depression Scale (GDS), Mini-mental state examination Korean Version (MMSE-K), and Visual Analogue Scale (VAS). In addition, noticeable improvement was observed in other accompanying symptoms.Conclusions: These results suggest that M&L Psychotherapy and Korean medical treatments might be effective for treating the psychiatric and physical symptoms of hospitalized North Korean Defectors.