On October 12, 2008, as a successful result of Six-Party Talks, the U.S. government de-listed North Korea from the terrorism sponsoring states which was the one of main reasons of economic sanctions against North Korea. Although it could not be viewed as an imminent and irreversible one, the softening of the Bush administration’s positions represents a major change in distrustful interactions between both countries. What did make the Bush change its policy course against North Korea which had continued for a quite long time? Regarding the real effectiveness of sanctions against North Korea, the study seeks to focus on the changing perspectives on economic sanctions in the U.S.-DPRK relations and the changing strategy of the Bush administration toward North Korea. Eventually the Bush administration did not give up the basic attitudes on the economic sanctions against North Korea, but redesigned its existing unilateral economic sanctions to build multilateral governance over North Korea which could invite the cooperation of other neighbor countries, and secure the validity of North Korean policy easier.