Purpose: The purpose of this study was to develop a program to improve the cultural competence of nursing students related to North Korean defectors and to investigate the effectiveness of the program. Methods: There were 36 nursing students in the experimental group and 30 in the control group, who were recruited from a university in I-city, Korea. A Chi-square, t-test, and ANOVA with the SPSS/Win 21.0 program were used to analyze the data. Results: After the intervention, the experimental group showed a statistically significant increase in the total score for multicultural awareness toward North Korean defectors over the control group (t=0.85, p=.026). Scores for cognitive area (t=0.89; p=.037), ritual area (t=-0.10, p=.915), and action area (t=1.18, p=.031) increased, but the conscious area score was not statistically significant. The experimental group showed a statistically significant increase in the total score for multi-cultural efficacy for North Korean refugees (t=0.36, p=.030). Scores for cognitive area (t=0.63; p=.029), working area (t=0.05, p=.955), and emotional area (t=0.79 and p=030) increased, but the working area score was not statistically significant. Conclusion: It was found that the program to promote multicultural efficacy related to North Korean defectors applied in this study was effective in enhancing multicultural awareness and efficacy of nursing students.

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