In this study, the National Cancer Center and Hanawon sought ways to develop the "2020 Disease Language Communication Casebook through North and South Korean defectors," the first collaborative project in the health care sector. To this end, Chapter 2 examined the need and significance of researching the health literacy of North Korean defectors, and Chapter 3 proposed the development of the "Inter-Korean Disease Language Communication Casebook" as non-medical personnel. First, we proposed "understanding the entire South Korean medical system, how to use medical institutions, understanding the post-test diagnosis and prescription process, and the importance of taking accurate medication" to design health support education for North Korean defectors as non-medical personnel. Second, to design educational contents for North Korean medical reality and socio-cultural context for North Korean defectors, we proposed "understanding North Korean medical characteristics, understanding chronic pain, and understanding health behavior characteristics of North Korean defectors." Third, we proposed the development and application of support programs for North Korean medical experiences to enter the South Korean medical field. To this end, it emphasized the need for the interest and cooperation of the Ministry of Unification, the Ministry of Gender Equality and Family, municipal and provincial governments and medical institutions to support North Korean defectors as part of the community network. This study has a fundamental limitation that specific content about the medical field is difficult to take expertise as it is proposed from a non-medical perspective. However, it is hoped that the issue of improving health literacy of North Korean defectors will be discussed in earnest by experts in various fields.